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The thin tip needle, therefore, seems to be advantageous for the patient. In the SN group, one patient was excluded after randomization at her own request, and three were excluded due to protocol violations, resulting in 124 assessed PP (Fig. . Ovarian stimulation and oocyte aspiration, ovarian stimulation was performed using follicle-stimulating hormone or human menopausal gonadotrophin in combination with GnRH agonists or antagonists according to each clinic's routines. ) or the SN with an outer diameter.4 mm (17 gauge) and inner diameter of 1 mm for the whole length of the needle (Fig. . Ultrasound-guided transvaginal follicle aspiration has become the gold standard for oocyte pick-up (OPU) in human in vitro fertilization (IVF) over the last 20 years. In this study, one such factor that could be of importance is the fact that the doctor was not blinded to the type of needle. The aim of this study was to compare the pain experience during oocyte retrieval between a newly designed thinner needle and a thicker. Thus, only the part of the needle that penetrates into the tissues is reduced in diameter. The patient population consisted of all patients who were going to have oocyte aspiration performed at the four clinics during the study period. Of frozen embryos.30.04 (012).28.89 (08).80 Proportion of good quality of embryos.188.8.131.52.64 Implantation rate.184.108.40.206.40 Clinical pregnancy rate.8.4.48 Open in a separate window Analysis per protocol population. Furthermore, significantly more patients had less vaginal bleeding than expected. Since oocyte retrieval under local anaesthesia can be painful, different methods of analgesia have been evaluated. We consider that this is of minor relevance since the nurse's involvement was limited to asking the patient to mark the VAS. Evaluating pain experience during oocyte retrieval is difficult since there are so many factors that influence pain, fear of pain, anxiety, type of analgesia, physician's skill and technical factors such as needle diameter and sharpness. A Cochrane review of such studies concluded that there is insufficient evidence to determine the best method of pain relief for OPU.